You Need To Know Celebrex
This is a summary of the most important information about Celebrex (Celecoxib).
For details, talk to your healthcare provider.
FDA ALERT-[4/7/2005]: Celebrex has been linked to an increased risk of
serious cardiovascular (CV) events (such as heart attack or stroke) which
appears to be a risk shared by all medicines called non-steroidal anti-inflammatory
drugs (NSAIDs) (excluding aspirin). FDA has requested that the package
insert (labeling) for all NSAIDs, including Celebrex, be revised to include
a “boxed” or serious warning to highlight the potential increased
risk of CV events, and the well known risk of serious, and potentially
life-threatening, stomach bleeding. FDA has also requested that the package
insert for all NSAIDs be revised to state that patients who have just
had heart surgery should not take these medicines.
What is Celebrex?
Celebrex is used to:
* relieve symptoms of osteoarthritis (the arthritis caused by age-related “wear
and tear” on bones and joints)
* relieve symptoms of rheumatoid arthritis in adults
* manage acute pain in adults (like the short term pain you can get after
a dental or surgical operation)
* treat painful menstrual cycles
* reduce the number of colon and rectum growths (colorectal polyps) in
patients with a disease called Familial Adenomatous Polyposis (FAP).
FAP is an inherited disease in which the rectum and colon are covered
with many polyps. Celebrex is used along with the usual care for FAP
patients such as surgery and exams of the rectum and colon.
Not Take Celebrex?
Do not take Celebrex
* have had an allergic-type
reaction to sulfa medicines.
* have had asthma, hives or allergic-type reactions after taking
aspirin or other NSAID (nonsteroidal anti-inflammatory drugs)
you have asthma, you may have aspirin-sensitive asthma. If an
aspirin-sensitive asthmatic takes aspirin it can cause severe narrowing
of the airway
and even death. Since this type of reaction also has occurred
after taking NSAIDs Celebrex should not be given to aspirin-sensitive
patients.Some examples of NSAIDs are ibuprofen (Motrin, Advil), naproxen
(Naprosyn, Aleve), diclofenac (Voltaren, Cataflam), and ketoprofen
can ask your doctor or pharmacist for a complete list of these medications.
are pregnant, especially during your last 3 months
What are The Risks?
Celebrex and other NSAID medicines can cause serious problems such
* Stomach ulcers that bleed. The chance of this serious problem increases
the longer you take Celebrex, but it can also happen suddenly. Stop
taking Celebrex and call your healthcare professional right away
if you get
a burning stomach pain, black bowel movements that look like tar,
or vomit that looks like blood or coffee grounds.
* Liver damage. Some of the warning signs of liver damage are nausea,
vomiting, tiredness, loss of appetite, itching, yellow coloring of
skin or eyes, “flu-like” symptoms and dark urine. If
this happens, stop taking Celebrex and call your healthcare professional
* Kidney problems that include sudden kidney failure or worsening
of kidney problems that you already have.
* Fluid retention (holding of water in your body) and swelling. Fluid
retention can be a serious problem if you have high blood pressure
or heart failure.
In addition to the
serious side effects listed above, some
common, but less serious side effects with Celebrex may include:
* upper respiratory tract infection (a "cold")
* sinus inflammation
* stomach pain
What Should I Tell
My Healthcare Professional?
your healthcare professional if you:
* have heart problems or high blood pressure
* have liver or kidney problems
* have or had stomach ulcers or stomach bleeding
* have asthma
* are allergic to aspirin or other NSAID medicines
* are trying to become pregnant, are already pregnant, or are breast-feeding
Any Interactions With Drugs or Foods?
Tell your healthcare
professional about all the medicines you take, including prescription
and non-prescription medicines,
and herbal supplements.
Some medicines may affect how Celebrex works or Celebrex
affect how your other medicines work. Your healthcare professional
have to adjust
your dose or watch you closely if you take any of the following
* certain blood pressure medicines called ACE inhibitors
* fluconazole or ketoconazole
Celebrex FDA Approved
Patient Information Sheet Revised 04/2005
Patient Information Sheet - Questions? Call Drug Information